I've reacted to most drugs way better since being on escitalopram, compared to before.
The only bad experience I've had so far (that wasn't primarily caused by excessive alcohol consumption) was when I had a couple of drinks of whiskey, some weed, and then nitrous oxide.
The NOS made me feel like my head was violently shaking or vibrating. I collapsed in my chair, trying to convince myself that this would be over soon, and said "wow, that nos really fucked me up" Someone else suggested I have another one, saying it would make me feel better. I was like, "yeah, I'll have some nos to take the edge off the first nos, great idea"
I think I actually did end up having another hit.